Fri Aug 19 2022

31 articles - From Friday Aug 12 2022 to Friday Aug 19 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Clin J Am Soc Nephrol

The Effect of Gender-Affirming Hormone Therapy on Measures of Kidney Function: A Systematic Review and Meta-Analysis.

Gender-affirming hormone therapy increases serum creatinine in transgender men and does not affect serum creatinine in transgender women. The effect on gender-affirming hormone therapy on other kidney function biomarkers and measured GFR is unknown. Clinical trial registry name and registration number Change in Kidney Function Biomarkers in Transgender Persons on Gender Affirmation Hormone Therapy-A Systematic Review and Meta-Analysis, CRD42020214248.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Adult-Onset Focal Segmental Glomerulosclerosis With Steroid-Dependent Nephrotic Syndrome Caused by a Novel TBC1D8B Variant: A Case Report and Literature Review.

To our knowledge, this is the first report identifying a pathogenetic mutation located in TBC domain of TBC1D8B in an adult-onset FSGS patient with steroid dependent NS. With this report, we broaden the clinical and genetic spectrum of X-linked genetic FSGS.

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Clinical Trial Considerations in Developing Treatments for Early Stages of Common, Chronic Kidney Diseases: A Scientific Workshop Cosponsored by the National Kidney Foundation and the US Food and Drug Administration.

Attendees also concluded that cost analyses should be holistic and include aspects beyond direct savings for treatment of kidney failure; and that safety data should be collected outside/beyond the duration of a clinical trial. Successful drug development and implementation of effective therapies will require collaboration across sponsors, patients, patient advocacy organizations, medical community, regulators, and payors.

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Clin J Am Soc Nephrol

Incidence and Risk Factors for Dialysis Reinitiation among Patients with a History of Dialysis Dependency.

Over one in five patients with recovery of kidney function after kidney failure restarted dialysis within 3 years.

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Clin Kidney J

Idiopathic nephrotic syndrome relapse following COVID-19 vaccination: a series of 25 cases.

This case series suggests that, in rare patients, COVID-19 vaccination may trigger INS relapse that is generally easy to control. These findings should encourage physicians to persuade their patients to complete the COVID-19 vaccination schedule.

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J Am Soc Nephrol

Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function.

Targeting the CCL8-CCR8 axis is a promising measure to reduce early kidney allograft inflammation.

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Correlates and Consequences of an Acute Change in eGFR in Response to the SGLT2 Inhibitor Dapagliflozin in Patients with Chronic Kidney Disease.

Among patients with CKD and albuminuria treated with dapagliflozin, an acute reduction in eGFR (from baseline to 2 weeks) is not associated with higher rates of CKD progression.

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Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins Leading to Secondary Hyperparathyroidism.

Background Secondary hyperparathyroidism (SHP) is a common complication of CKD that increases morbidity and mortality. In experimental SHP, increased parathyroid hormone (PTH) expression is due to enhanced mRNA axis thus drive SHP.

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KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease.

Background Ciliogenesis-associated kinase 1 ( increased KLC3.

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Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD.

Among SPRINT participants with CKD, worse tubular secretion was associated with greater risk of AEs, independent of eGFR and albuminuria.

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SARS-CoV-2 Infection during the Omicron Surge among Patients Receiving Dialysis: The Role of Circulating Receptor-Binding Domain Antibodies and Vaccine Doses.

Among patients receiving dialysis, a third mRNA vaccine dose enhanced protection against SARS-CoV-2 infection during the Omicron-dominant period, but a low circulating RBD antibody response was associated with risk for infection independent of the number of vaccine doses. Measuring circulating antibody levels in this high-risk group could inform optimal timing of vaccination and other measures to reduce risk of SARS-CoV-2 infection.

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Sex Differences in Age-Related Loss of Kidney Function.

Among middle-aged and elderly individuals in the general population, decline in the mean GFR in women was slower than in men, independent of health status.

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Kidney Int

Integrating basic science with translational research: the 13th International Podocyte Conference 2021.

As well as updates on improving diagnosis and potential new therapies, the Patient Day included a PodoArt competition, exercise and cooking classes with practical nutrition advice and inspirational stories from patients and family members. This review summarises the exciting science presented during the 13th International Podocyte Conference and demonstrates the resilience of researchers during a global pandemic.

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Kidney outcomes in patients with diabetes mellitus did not differ between individual sodium-glucose cotransporter-2 inhibitors.

A multitude of sensitivity analyses confirmed the robustness of our primary results. Thus, we found that there was no significant difference in the annual eGFR decline slopes between patients taking different SGLT2 inhibitors.

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Too bright for 2 dimensions: recent progress in advanced 3-dimensional microscopy of the kidney.

Combined with novel machine-learning algorithms, these approaches offer unprecedented options for large-scale and automated analysis of kidney structure and function. This review provides a brief overview of these emerging imaging technologies and presents key examples of how these approaches are already used to study the normal and the diseased kidney.

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Nephrol Dial Transplant

Increasing numbers and improved overall survival of patients on kidney replacement therapy over the last decade in Europe: an ERA Registry study.

This study showed an overall increase in the incidence and prevalence of KRT for ESKD as well as an increase in the KRT patient survival over the last decade in Europe.

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Treatment of secondary hyperparathyroidism in non-dialysis CKD: an appraisal 2022s.

We further comment on extended-release calcifediol (ERC) as a new differential therapeutic option now also available in Europe, and on a potentially novel understanding of a required vitamin D saturation in more advanced CKD stages. There is no doubt, however, that knowledge gaps will remain in this issue unless powerful RCTs with hard and meaningful endpoints are performed.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Kidney Dis

Calciphylaxis and Kidney Disease: A Review.

We also discuss the unique histopathological features of calciphylaxis and contrast it with those of other forms of general vessel calcification. This review emphasizes the need of multidisciplinary collaboration including nephrology, dermatology, and palliative care to ultimately provide the best possible care to patients with calciphylaxis.

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Correction of Hypokalemia in Peritoneal Dialysis Patients May Decrease Peritonitis Risk.

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Clin J Am Soc Nephrol

Advancing Kidney Health Equity: Influences of Gender-Affirming Hormone Therapy on Kidney Function.

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Kidney Int

What can we learn from kidney organoids?

Indeed, at present we are still finding out what we can learn and what we cannot learn from this approach. In this review, we will summarize the approaches available to generate models of the human kidney from stem cells, the existing successful applications of kidney organoids, their limitations, and remaining challenges.

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Nat Rev Nephrol

MicroRNAs in kidney injury and disease.

Use of combinations of miRNAs together with other molecular markers could potentially improve diagnostic or predictive power and facilitate clinical translation. In addition, targeting specific miRNAs at different stages of disease could be a promising therapeutic strategy.

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Letters&Replies

Letters to the editors and authors’ replies

Kidney Int

A rapid decline in the anti-receptor binding domain of the SARS-CoV-2 spike protein IgG titer in kidney transplant recipients after tixagevimab-cilgavimab administration.

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Others

all remaining publications eg case reports, images of the month, etc…

Clin J Am Soc Nephrol

How I Manage Hypertension and Proteinuria Associated with VEGF Inhibitor.

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Reducing the Risks of Home Dialysis Innovation and Uptake.

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Kidney Int

Acute Kidney Injury in Patients Receiving Pembrolizumab Combination Therapy versus Pembrolizumab Monotherapy for Advanced Lung Cancer.

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Clinicopathologic and Proteomic Characteristics of Intratubular Cytoplasmic AL-Amyloidosis.

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How does diabetes cause susceptibility to COVID in the kidney: new clues provided by organoids.

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The effectiveness and safety of mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines among individuals with chronic kidney diseases.

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USE OF REMDESIVIR IN KIDNEY TRANSPLANT RECIPIENTS WITH SARS-COV-2 OMICRON INFECTION.

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Nat Rev Nephrol

A polygenic score predicts CKD across ancestries.

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